Quantification of bioactive diet-derived microbiome-dependent metabolites (MDMs).

Research

The gut microbiota produces a vast and structurally diverse array of small molecules. Remarkably, bacterial processing of ingested food and drug compounds alone accounts for the production of thousands of metabolites, many of which are not well studied despite possessing disease connections. The Guthrie lab aims to decipher the basic biology, sources of heterogeneity, and opportunities to modulate diet-derived microbiota-dependent metabolites (MDMs) for beneficial host signaling.